RBC Rheology in Microcirculation
RBC Deformability
Healthy RBCs
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Flow through a vessel which is smaller than RBCs due to deformabilit
Hardened RBCs
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Have some difficulty in flowing small vessels, which may cause followings: Local hypertension, Local vascular injury and sclerosis, Hypoxia to tissues
RBC Aggregation
Healthy RBCs
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easy to disaggregate and enter small vessels in n efficient manners.
Hyper-aggregating RBCs
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Do not dis-aggregate and cause followings: Local hypertension, vascular sclerosis, Hypoxia to local tissues
RBC Rheology in DM Complication
Patients with diabetes mellitus(DM) have hyperglycemia and elevated fibrinogen that leads to impaired RBC deformability, RBC aggregation, and Cricital Shear Stress.
- Hyperglycemia leads to non-enzymatic glycation and oxidative stress which increases Glycosylated Hemoglobin Type A1C and membrane glycation, Peroxidation of lipid membrane leads to impaired red blood cell deformability.
RheoScan can diagnose diabetic complications such as diabetic nephropathy, diabetic retinopathy, and metabolic syndrome with RBC deformability / Critical Shear Stress.
The best treatment starts with early detection
Normal
metabolism
Early metabolic dysregulation
Prediabetes
Type 2 Diabetes
Metabolic Syndrome
T2DM Complications
Glucose monitoring is not enough to detect T2DM(type 2 diabetic mellitus) complications.
The most serious problem is the late detection of the Diabetic Mellitus complications at their late stages
RheoScan system provides clinicians with easy and rapid identification of a patient’s diabetic complication status at point-of-care (POC) setting.
Now, RheoScan based on the innovative technology and clinical validation is ready to answers the calls from the hospitals and clinics.
